February 22, Copyright: MeS increased postnatal mammary gland development and generated prominent duct patterns with markedly increased CtBP1 and Cyclin D1 expression. Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Eur Arch Otorhinolaryngol. Expression profiling studies using P4HA1 modulated prostate cells suggested regulation of Matrix metalloproteases 1.
Pregnane X-receptor promotes stem cell-mediated colon cancer relapse
Google Scholar Articles by Richer, J. All relevant data are within the paper and its Supporting Information files. Ref Eur J Pharmacol. C-terminal binding proteins CtBPs were initially identified as binding partners for the E1A-transforming proteins. The expression stability values were 0.
Pregnane X receptor | 1I. Vitamin D receptor-like receptors | IUPHAR/BPS Guide to PHARMACOLOGY
The expression stability values were 0. Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. Clin Chim Acta ; Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concomitant hypomethylation of key intestinal cell fating genes. Additional detailed and comparative mechanistic studies are required to predict the effect of PXR transcript variant expression on carcinogenesis, therapeutic response, and the development of toxicity. B-cell lymphoma 3 Bcl3 is a proto-oncogene upregulated in a wide range of cancers, including breast cancer. The expression of genes encoding three transcription factors [pregnane xenobiotic receptor PXR , constitutive androstane receptor CAR , aryl hydrocarbon receptor AhR ] was also investigated.
S 11 [pii] In this review, we highlight some of the most recent advances and discoveries in the field. Mol Endocrinol ; Disease Breast cancer [ICD9: Ref Eur J Pharmacol. Transcriptional misregulation in cancer. A comprehensive picture of epigenetic patterns in normal cells is now emerging; these patterns are disturbed in human diseases such as cancer.